Nano Biotechnology in Neurodegenerative Diseases and Bioavailability of Cur Cumin.

Introduction- Curcuma longa is globally well-known medicinal plant that belongs to the ginger family (Zingiberaceae).It is widely grown in Asian countries mostly China and India. Used as a spice, a dye, and a cosmetic Curcumin, a key component of Curcuma longa found in the plant’s rhizome, has a wide range of pharmacological properties. Curcumin is a polyphenolic compound derived from the dietary spice turmeric that has anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic properties, as well as therapeutic efficacy against a variety of human diseases such as cancer, cardiovascular disease, diabetes, arthritis, neurological disease, and Crohn’s disease. It also modulate intracellular signaling pathways that control cancer cell proliferation, and death, ( Anand et al,. 2007) Despite its potential biological and antioxidant capabilities, curcumin’s medical applications are limited due to its poor water solubility and low absorption., (Jäger et al,. 2014). . Curcumin’s bioavailability will most likely be improved in the near future, and this will bring this interesting natural substance to the forefront of therapeutic medicines for human diseases.

Nano Biotechnology :-
Alzheimer’s and Parkinson’s diseases are leading cause of cognitive decline in populations, which affect aged people and cause clinical symptoms such as progressive loss of memory, reasoning, and cognitive abilities, caused by oxidative stress through production of reactive oxygen species, they are superoxide ions (O2• ‾), hydroxyl radical (•OH), singlet oxygen (1O2)etc. Antioxidants can, therefore inhibit oxidative-stress-induced neurotoxicity. Cur cumin bioavailability will be influenced by the final particle size and stability, and can be improved with the latest nanoparticle technologies. thus nanotechnology applications offer a new therapy platform for neurodegenerative diseases, consequently Nano cur cumin might break through blood-brain barrier crucially to treat neurodegenerative diseases, like Parkinson and Alzheimer’s diseases, Developing a successful Nano medicine will result in treatment of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Ms. Zayyanu Tukur, Ph.D Scholar, School of Agriculture Sciences, Career Point University, Kota

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