Pharmacological Studies: –
1. Antibacterial Activities :-
S.Chanda screened out thirteen plants including Psoralea corylifolia for their in vitro antibacterial potentiality against five medically important bacterial strains. Amongst the thirteen plants screened, Psoralea corylifolia was found having best antibacterial activity. The seeds P corylifolia were extracted successively with petroleum ether, 1, 4-dioxan, acetone, methanol and N, N-dimethylformamide (DMF). The antibacterial activity of these extract was carried out against five microorganism namely Proteus morganii, Alcaligenes faecalis, Enterobacter aerogenes, Staphylococcus epidermidis and Bacillus megaterium by agar disc diffusion method. All the extracts were active against S. epidermidis and P morganii while none of the extract was active against A fecalis. Dioxan extract showed the maximum antibacterial activity.
2. Antifungal Activity :-
N. Rajendra Prasad reported the qualitatively antifungal activity of crude extract Psoralea corylifolia seed against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum gypseum by the disc diffusion method on a Sabouraud dextrose agar (SDA) medium. Dried seed powder of Psoralea corylifolia was extracted successively with 250 ml of solvents of increasing polarity such as petroleum ether, diethyl ether, benzene, chloroform, acetone, methanol, ethanol and water.
3. Antitumor Activity :-
P.G. Latha conducted the antitumour activity of Psoralea corylifolia seeds extract (PCSE) in mice. Balb/c male mice (20-25 g), housed under standard environmental conditions, were used. Three groups of eight mice each were transplanted i.p. (Intraperitoneally) with 1×106 EAC (Erlich ascites tumour) cells. After 24 h, the first group was injected with PCSE 100mg/kg and second group was injected with PCSE 200mg/kg i.p. The third group, serving as the control, was given normal saline (0.25 ml, i.p.). Treatment was continued for 35 days or till death of animals.
4. Ant filarial Activity :-
Qamaruddin et al. carried out ant filarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi. They studied the effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia, on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro.
5. Antiplatelet Activity :-
The methanolic extract of the seeds of Psoralea corylifolia L. was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid, collagen, and platelet activating factor in a study carried out by Wei-Jern Tsai et al.
Ms. Shama Parveen, Assistant Professor, School Of Health & Allied Sciences, Career Point University, Kota